Source comparison
Comparison Table: MK-677 Dosing Protocols
| Protocol | Timing | Gastric Tolerance | Peak GH Timing | Total 24h GH Output | Best For | Professional Assessment ||—|—|—|—|—|—|| Fasted Morning | Upon waking, 60 min before food | Low. Nausea in 65%+ users by week 2 | 60–90 minutes post-dose | 100% baseline
This comparison does not assign a generated winner or score.
- | Protocol | Timing | Gastric Tolerance | Peak GH Timing | Total 24h GH Output | Best For | Professional Assessment ||—|—|—|—|—|—|| Fasted Morning | Upon waking, 60 min before food | Low. Nausea in 65%+ users by week 2 | 60–90 minutes post-dose | 100% baseline | Users with no GI sensitivity, short-term protocols | Fastest absorption but poorest adherence. Only sustainable for 25–30% of users long-term || Pre-Meal (20–30 min) | 20–30 min before moderate meal | Moderate. Nausea in 20–30% users | 70–100 minutes post-dose | 96–98% of fasted baseline | Users with mild GI sensitivity, training-timed dosing | Best balance of absorption speed and tolerability for most users || Immediate Post-Meal | Directly after finishing meal | High. Nausea in fewer than 10% users | 120–150 minutes post-dose | 95–100% of fasted baseline | Users with GERD, gastritis, ulcer history | Highest adherence rate, minimal efficacy trade-off. Optimal for 12+ week protocols || Evening with Dinner | 2–3 hours before bed