Source comparison
Comparison Table: Semax vs Related Nootropic Peptides
Semax (Amidated) BDNF upregulation, dopamine/serotonin modulation, inhibition of enkephalin degradation 60–90 minutes Cognitive enhancement, neuroprotection in ischemic injury, ADHD symptom modulation Moderate (7 amino acids, standard SPPS) Gold standard for A
This comparison does not assign a generated winner or score.
- Semax (Amidated)
- BDNF upregulation, dopamine/serotonin modulation, inhibition of enkephalin degradation
- 60–90 minutes
- Cognitive enhancement, neuroprotection in ischemic injury, ADHD symptom modulation
- Moderate (7 amino acids, standard SPPS)
- Gold standard for ACTH-derived nootropics. Well-characterised mechanism, reproducible synthesis, extensive Russian clinical data
- Selank
- Anxiolytic via GABAergic modulation, IL-6 suppression, tuftsin analogue
- 20–30 minutes (non-amidated degrades faster)
- Anxiety reduction, immune modulation, stress resilience
- Moderate (6 amino acids)
- Complementary to Semax but distinct. Targets anxiety/stress pathways rather than cognitive performance directly
- P21 (CNTF Fragment)
- CNTF receptor activation, neurogenesis in hippocampus
- Unknown (limited pharmacokinetic data)
- Memory consolidation, neuroplasticity enhancement
- High (derived from ciliary neurotrophic factor structure)
- Emerging research compound. Mechanism promising but less characterised than Semax; our P21 formulation follows strict synthesis protocols
- Cerebrolysin
- Multi-peptide mixture (neurotrophic factors from porcine brain)
- Variable (contains multiple active components)
- Post-stroke recovery, traumatic brain injury, dementia
- N/A (biological extraction, not synthetic)
- Established clinical use in Europe/Asia but compositional variability limits reproducibility. Different mechanism class than synthetic peptides like Semax
- Dihexa
- Hepatocyte growth factor (HGF) mimetic, potent synaptogenesis inducer
- 2–4 hours (estimated, limited human data)
- Alzheimer's research, cognitive decline models
- High (requires multi-step organic synthesis)
- Extremely potent (7 orders of magnitude more active than BDNF in some assays) but human safety data minimal. Our Dihexa is research-grade only