Source comparison
CrossFit Athletes MOTS-C Protocol: Comparison of Dosing Strategies
2x per week 10mg 20mg Simplified schedule, lower injection frequency, steady AMPK activation May miss peak training days if not timed correctly Best for athletes prioritising convenience and consistent weekly volume 3x per week 5–7.5mg 15–22.5mg Matches high-f
This comparison does not assign a generated winner or score.
- 2x per week
- 10mg
- 20mg
- Simplified schedule, lower injection frequency, steady AMPK activation
- May miss peak training days if not timed correctly
- Best for athletes prioritising convenience and consistent weekly volume
- 3x per week
- 5–7.5mg
- 15–22.5mg
- Matches high-frequency training splits, allows pre-workout dosing on key sessions
- Requires more planning and injection discipline
- Ideal for competitive athletes training 5–6 days per week with structured programming
- Pre-workout only
- 5–10mg
- Variable (10–30mg depending on training frequency)
- Maximises synergy with acute training stress, targets AMPK activation during metabolic demand
- Inconsistent weekly exposure, harder to track cumulative effect
- Best for athletes who want direct performance impact on specific training days
- Post-workout only
- Variable
- Enhances recovery signalling, reduces inflammatory response, supports glycogen resynthesis
- Misses the acute metabolic benefit during exercise
- Suitable for athletes prioritising recovery over in-session performance