Source comparison
DAC vs No-DAC: Two Distinct Compounds
CJC-1295 exists in two functionally different forms, and the distinction matters significantly for protocol design. CJC-1295 with DAC includes a Drug Affinity Complex, a reactive lysine linker that covalently bonds to serum albumin after injection. This albumi
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- CJC-1295 exists in two functionally different forms, and the distinction matters significantly for protocol design.
- CJC-1295 with DAC includes a Drug Affinity Complex, a reactive lysine linker that covalently bonds to serum albumin after injection. This albumin binding shields the peptide from degradation and extends its effective half-life to 6 to 8 days. The result is a sustained, continuous elevation of GH signaling that requires only one to two injections per week. However, this continuous stimulation means GH release is more tonically elevated rather than sharply pulsatile.
- CJC-1295 without DAC, also called Modified GRF (1-29) or Mod GRF, retains the four stabilizing amino acid substitutions but omits the albumin-binding complex. Its half-life is approximately 30 minutes, meaning each injection produces a relatively brief amplification of the natural GH pulse before clearing. This shorter duration more closely mimics the body's endogenous pattern of intermittent GHRH signaling.