Source comparison
Does MK-677 Help Frailty Research?: Functional Outcome Comparison
Lean Body Mass Change +1.1 to +2.7 kg +0.8 to +1.5 kg +0.3 to +0.6 kg MK-677 produces the largest lean mass gain but requires concurrent training for functional translation IGF-1 Elevation +60% to +90% above baseline No significant change Unique hormonal mecha
This comparison does not assign a generated winner or score.
- Lean Body Mass Change
- +1.1 to +2.7 kg
- +0.8 to +1.5 kg
- +0.3 to +0.6 kg
- MK-677 produces the largest lean mass gain but requires concurrent training for functional translation
- IGF-1 Elevation
- +60% to +90% above baseline
- No significant change
- Unique hormonal mechanism. No other intervention consistently raises IGF-1 in elderly populations
- Grip Strength Improvement
- +1 to +3 kg (variable, training-dependent)
- +3 to +5 kg
- +0.5 to +1.5 kg
- Strength gains lag behind lean mass increases unless structured resistance training is included
- Gait Speed Change
- Minimal to no change in most trials
- +0.05 to +0.1 m/s
- MK-677 alone does not improve gait speed. Mobility interventions still required
- Adverse Events (edema, glucose elevation)
- 15–25% mild edema; 5–8 mg/dL glucose rise
- Minimal
- Side effect profile acceptable for research populations but requires metabolic monitoring