Source comparison
Dosing Comparison
Subcutaneous injection Oral Reported starting dose Community sources describe 5 mg SC, 2-3x/week Standard clinical initiation is 500 mg/day oral Reported maintenance dose Community sources describe 10 mg SC, 3x/week Prescribed doses range from 1,000-2,000 mg/d
This comparison does not assign a generated winner or score.
- Subcutaneous injection
- Oral
- Reported starting dose
- Community sources describe 5 mg SC, 2-3x/week
- Standard clinical initiation is 500 mg/day oral
- Reported maintenance dose
- Community sources describe 10 mg SC, 3x/week
- Prescribed doses range from 1,000-2,000 mg/day
- Frequency
- 2-3 times per week (community protocols)
- Daily or twice daily
- Cycling
- Community protocols describe 8-12 week cycles with 4-week breaks
- Typically continuous (prescribed)
- Storage
- Requires reconstitution and refrigeration
- Room temperature tablet
- Onset
- Community reports describe effects emerging over 2-4 weeks
- Clinical glucose-lowering effects documented within 1-2 weeks
- All MOTS-c dosing information above is derived from community self-reports and preclinical rodent data, not from controlled human trials. Rodent studies have used intraperitoneal doses roughly equivalent to 0.5-5 mg/kg, but interspecies dose translation is imprecise.