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GHRP-2 vs GHRP-6: Growth Hormone Secretagogue Comparison

GHRP-2 (pralmorelin) and GHRP-6 are synthetic hexapeptide growth hormone secretagogues that stimulate GH release through the ghrelin receptor (GHSR-1a). GHRP-2 produces slightly stronger GH pulses with moderate appetite stimulation and minimal cortisol/prolact

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  • GHRP-2 (pralmorelin) and GHRP-6 are synthetic hexapeptide growth hormone secretagogues that stimulate GH release through the ghrelin receptor (GHSR-1a). GHRP-2 produces slightly stronger GH pulses with moderate appetite stimulation and minimal cortisol/prolactin effects, making it the more selective option. GHRP-6 produces strong GH release with pronounced hunger stimulation and slightly more cortisol/prolactin elevation. The key differentiator is appetite: GHRP-6 causes intense hunger while GHRP-2 is more manageable. Both are commonly paired with GHRH analogs (CJC-1295 or sermorelin) for synergistic GH release.
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