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GHRP-2 vs GHRP-6 vs Ipamorelin: How Do the Secretagogues Compare?

The GHRP-2 vs ipamorelin comparison is probably the most-searched question about this compound, and it deserves a rigorous, non-hyped answer. All three peptides are ghrelin-receptor agonists that release GH through GHS-R1a. They differ in potency, appetite eff

This comparison does not assign a generated winner or score.

  • The GHRP-2 vs ipamorelin comparison is probably the most-searched question about this compound, and it deserves a rigorous, non-hyped answer. All three peptides are ghrelin-receptor agonists that release GH through GHS-R1a. They differ in potency, appetite effect, and — most importantly — hormonal selectivity.
  • Class
  • First-gen GHRP
  • Second-gen GHRP
  • Selective GHS-R1a agonist
  • GHS-R1a
  • Relative GH potency
  • Lower
  • Higher than GHRP-6
  • Comparable GH release, high selectivity
  • Appetite / ghrelin-like hunger
  • Pronounced
  • Moderate
  • Minimal
  • ACTH / cortisol effect
  • Present
  • Present, dose-dependent
  • Negligible in studies
  • Prolactin effect
  • Present at higher doses
  • Defining trait
  • The original prototype
  • Potency
  • Selectivity
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