Source comparison
Hexarelin Mechanism of Action Detailed: Receptor Comparison
GHSR-1a (pituitary) Anterior pituitary somatotrophs 0.4–0.7 nM Calcium mobilisation → GH exocytosis GH-dependent Drives acute GH pulse release within 15–30 minutes GHSR-1a (cardiac) Cardiomyocytes, vascular endothelium 0.5–0.9 nM PI3K/Akt activation → anti-apo
This comparison does not assign a generated winner or score.
- GHSR-1a (pituitary)
- Anterior pituitary somatotrophs
- 0.4–0.7 nM
- Calcium mobilisation → GH exocytosis
- GH-dependent
- Drives acute GH pulse release within 15–30 minutes
- GHSR-1a (cardiac)
- Cardiomyocytes, vascular endothelium
- 0.5–0.9 nM
- PI3K/Akt activation → anti-apoptotic signalling
- GH-independent
- Cardioprotection during ischemia-reperfusion injury
- GHSR-1a (hepatic)
- Hepatocytes, Kupffer cells
- 0.6–1.1 nM
- AMPK activation → lipid oxidation
- Reduces hepatic steatosis, improves insulin sensitivity
- CD36 scavenger receptor
- Cardiomyocytes, macrophages
- 15–25 nM (lower affinity)
- Modulates fatty acid uptake, ROS signalling
- Potential anti-inflammatory effects in cardiac tissue