Source comparison
HGH injections vs hormone peptides like sermorelin
Unlike HGH injections—which involve directly injecting a synthetic growth hormone— peptides like sermorelin and ipamorelin stimulate the natural release of HGH hormone from the pituitary gland. “This is better for long-term health optimization as well as lon
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- Unlike HGH injections—which involve directly injecting a synthetic growth hormone— peptides like sermorelin and ipamorelin stimulate the natural release of HGH hormone from the pituitary gland.
- “This is better for long-term health optimization as well as longevity,” Cho says. Injecting growth hormone directly has been linked to type 2 diabetes, gynecomastia (man boobs), swelling and joint pain, and a higher risk of certain cancers (4). Stimulating the pituitary gland with peptides like ipamorelin to make more growth hormone has none of these effects.
- Sermorelin has a half-life of around 11 to 12 minutes, meaning half of the peptide is processed by the pituitary gland within this time (5). According to a 2020 review, sermorelin can double growth hormone levels for up to 12 hours after injection, with levels peaking around the two-hour mark (1).
- There are no human clinical trials on ipamorelin’s ability to increase growth hormone (1). But, studies with mice suggest that ipamorelin’s half-life is longer than sermorelin—it lasts around 2 to 3 hours. Tesamorelin has a half-life of around 26 to 38 minutes (6). A longer half-life means ipamorelin and tesamorelin may trigger growth hormone production longer than sermorelin.