Source comparison
How to Boost Growth Hormone with Peptides: Protocol Comparison
Ipamorelin GHSR-1a agonist (selective) 200–300mcg Twice daily (morning, pre-bed) 12–16 weeks Clean GH pulse without cortisol/prolactin elevation. Best for long-term use Gold standard for body recomposition. Minimal side effects, longest receptor preservation G
This comparison does not assign a generated winner or score.
- Ipamorelin
- GHSR-1a agonist (selective)
- 200–300mcg
- Twice daily (morning, pre-bed)
- 12–16 weeks
- Clean GH pulse without cortisol/prolactin elevation. Best for long-term use
- Gold standard for body recomposition. Minimal side effects, longest receptor preservation
- GHRP-2
- GHSR-1a agonist (high affinity)
- 100–200mcg
- Twice daily
- 8–12 weeks
- Strongest GH amplification among GHRPs
- Higher GH output than ipamorelin but with mild appetite stimulation. Use for muscle retention during cuts
- Hexarelin
- GHSR-1a agonist (highest affinity)
- 100mcg
- 4–6 weeks
- Highest acute GH pulse amplitude
- Fastest desensitisation. Reserve for short-cycle aggressive protocols only
- CJC-1295 (no DAC)
- GHRH amplifier
- Twice daily (paired with GHRP)
- Continuous use
- Extends GH pulse duration 6–8 hours
- Essential synergistic amplifier. Never use alone, always pair with a GHRP
- Sermorelin
- GHRH analogue
- Once daily (pre-bed)
- Restores natural GH pulsatility in older adults
- Gentler GHRH option than CJC-1295. Preferred for age-related GH decline
- MK-677 (ibutamoren)
- Oral ghrelin mimetic
- 10–25mg
- Once daily
- Oral administration, consistent GH elevation
- Convenient but causes faster desensitisation than injectable GHRPs. Best for users who can't inject