Source comparison
How to Use MOTS-c for Exercise Mimetic Protocol: Dosing Comparison
This table compares MOTS-c dosing protocols documented in published research and common research applications, showing dose ranges, administration frequency, intended metabolic outcomes, and the contexts where each protocol appears. 2.5–5mg 2x per week Mainten
This comparison does not assign a generated winner or score.
- This table compares MOTS-c dosing protocols documented in published research and common research applications, showing dose ranges, administration frequency, intended metabolic outcomes, and the contexts where each protocol appears.
- 2.5–5mg
- 2x per week
- Maintenance AMPK activation, insulin sensitivity
- Sedentary populations, metabolic syndrome models
- Produces measurable glucose uptake improvement but limited mitochondrial biogenesis. Insufficient for performance enhancement
- 5–10mg
- 3x per week
- AMPK phosphorylation, mitochondrial biogenesis, endurance capacity
- Active populations, athletic performance research
- Validated dose range in USC Cohen Lab studies. Optimal balance between efficacy and cost for exercise mimetic protocols
- 10–15mg
- 2–3x per week
- Maximum AMPK activation, substrate utilization shift
- Elite athlete protocols, maximum metabolic intervention
- Marginal returns above 10mg. Dose-response curve plateaus; higher cost without proportional benefit
- 5mg pre-training only
- Variable (matches training days)
- Exercise-synergistic AMPK amplification
- Performance-focused protocols
- Most cost-effective for trained populations. Leverages endogenous exercise signal rather than replacing it