Source comparison
IGF-1 LR3 Reddit Reviews Community: Full Comparison
Lean mass gain (2–4 lbs) 58–62% 6–8 weeks 40–80mcg/day Modest hypertrophy; often confounded by water retention making true lean tissue gain hard to isolate Severe water retention 35–42% 3–7 days 60–100mcg/day Dose-dependent; driven by renal sodium reabsorption
This comparison does not assign a generated winner or score.
- Lean mass gain (2–4 lbs)
- 58–62%
- 6–8 weeks
- 40–80mcg/day
- Modest hypertrophy; often confounded by water retention making true lean tissue gain hard to isolate
- Severe water retention
- 35–42%
- 3–7 days
- 60–100mcg/day
- Dose-dependent; driven by renal sodium reabsorption. Not preventable with dietary sodium restriction alone
- Injection site inflammation
- 40–48%
- 24–72 hours post-injection
- All doses
- Immune-mediated response to high local IGF-1 concentration; rotating 8+ sites weekly reduces but doesn't eliminate
- Hypoglycemic episodes
- 28–35%
- 60–120 min post-injection
- Insulin-mimetic pathway activation; requires proactive carb intake before/during training. Reactive dosing often too late
- Joint pain / carpal tunnel symptoms
- 18–25%
- 10–21 days
- 80–120mcg/day
- Fluid retention in joint capsules and nerve compression from edema; resolves within 7–10 days post-cessation
- Discontinuation due to side effects
- 38–44%
- Variable
- High attrition rate suggests side effect burden exceeds anabolic benefit for nearly half of users who attempt protocols