Source comparison
Is MK-677 Safe According to Studies? (Type) Comparison
Elderly (65+ years). Chapman 1997 24 months 25mg daily Ankle edema (18%), increased appetite (transient), muscle pain (12%) Fasting insulin +15%, HOMA-IR +12%, no HbA1c change Safe for elderly with normal baseline glucose; requires quarterly glucose monitoring
This comparison does not assign a generated winner or score.
- Elderly (65+ years). Chapman 1997
- 24 months
- 25mg daily
- Ankle edema (18%), increased appetite (transient), muscle pain (12%)
- Fasting insulin +15%, HOMA-IR +12%, no HbA1c change
- Safe for elderly with normal baseline glucose; requires quarterly glucose monitoring
- Obese males. Svensson 1999
- 8 weeks
- Increased appetite, mild fluid retention
- Fasting insulin +24%, HOMA-IR +29%, reversed within 4 weeks post-discontinuation
- Short-term use shows reversible insulin resistance; longer duration unknown in this cohort
- GH-deficient adults. Svensson 1998
- 7 days
- Increased hunger, no serious AEs
- IGF-1 increased 50–90%, no glucose measured
- Acute GH/IGF-1 elevation confirmed without toxicity; insufficient duration for metabolic conclusions
- Healthy young males. Nass 2006
- Cortisol elevation (+18–22%), transient fatigue
- No fasting glucose change, insulin not measured
- Cortisol increase plateaus and reverses; no clinical hypercortisolism observed