Source comparison
Localized vs Systemic Dosing
Two injection strategies exist, and they change where you place the needle, not the calculation. Systemic dosing puts the full daily dose into a single subcutaneous site, usually the abdomen, to raise circulating IGF-1 LR3 throughout the body. Localized dosing
This comparison does not assign a generated winner or score.
- Two injection strategies exist, and they change where you place the needle, not the calculation. Systemic dosing puts the full daily dose into a single subcutaneous site, usually the abdomen, to raise circulating IGF-1 LR3 throughout the body. Localized dosing splits the dose into the specific muscles trained that day, based on the unproven theory that local concentration favors growth in those fibers.
- For localized work, divide the daily dose across target muscles. A 40 mcg daily dose split bilaterally across biceps becomes 20 mcg (2 units) per arm. Localized injection is intramuscular into the worked muscle belly rather than subcutaneous.
- The evidence for site-specific hypertrophy from localized IGF-1 LR3 in humans is anecdotal. Systemic IGF-1 still reaches local muscle and activates satellite cells through the IGF-1 receptor (Velloso, 2008, British Journal of Pharmacology). Whichever route you choose, review sterile injection technique in how to inject peptides.