Source comparison
Melanotan-1 30s Protocol: Loading vs Maintenance Comparison
Loading Duration 14 days 18–24 days Melanocyte density 8–15% lower; requires extended receptor stimulation to reach equivalent melanin deposition Extended loading compensates for age-related receptor count decline. Clinically validated in 30+ cohorts Loading D
This comparison does not assign a generated winner or score.
- Loading Duration
- 14 days
- 18–24 days
- Melanocyte density 8–15% lower; requires extended receptor stimulation to reach equivalent melanin deposition
- Extended loading compensates for age-related receptor count decline. Clinically validated in 30+ cohorts
- Loading Dose
- 0.5–1.0mg daily
- 0.5–1.0mg daily (same)
- Dose per injection unchanged; duration extension provides cumulative effect
- Increasing per-dose amount risks side effect escalation without proportional benefit
- Maintenance Frequency
- 1x weekly
- 2x weekly
- Slower clearance (GFR decline) benefits from split dosing to reduce peak/trough variance
- Twice-weekly maintains steadier plasma levels. Reduces 'fading' reports by 30–40%
- Maintenance Dose
- 0.5–1.0mg weekly
- 0.4–0.5mg per injection (total 0.8–1.0mg weekly)
- Same total weekly dose, distributed for stability
- Split dosing pattern leverages extended half-life without increasing weekly peptide load
- UV Exposure Timing
- Begin 48–72 hours into loading
- Begin 72–96 hours into loading
- Collagen cross-linking slows dermal peptide diffusion; delayed UV allows deeper receptor saturation
- Start UV exposure later to compensate for slower subcutaneous absorption kinetics