Source comparison
Melanotan-1 Photoprotection: Protocol Comparison
Standard Clinical 14–18 days daily (0.25mg) Twice weekly After visible baseline tan (day 14–18) High. Lasts 8–12 weeks with UVB The evidence-backed approach used in erythropoietic protoporphyria trials. Prioritizes safety and predictable results Accelerated (T
This comparison does not assign a generated winner or score.
- Standard Clinical
- 14–18 days daily (0.25mg)
- Twice weekly
- After visible baseline tan (day 14–18)
- High. Lasts 8–12 weeks with UVB
- The evidence-backed approach used in erythropoietic protoporphyria trials. Prioritizes safety and predictable results
- Accelerated (Type III–IV)
- 10–12 days daily (0.25mg)
- Three times weekly
- After moderate darkening (day 10–12)
- Moderate. Requires more frequent UVB to sustain
- Works for individuals with higher baseline melanin but increases nausea risk during loading
- Conservative (Type I–II)
- 21 days daily (0.20mg)
- After definitive tan development (day 21+)
- Very high. Slower onset but longest maintenance
- Recommended for burn-prone individuals or those with prior melanoma history (under physician oversight)
- Maintenance-Only (Post-Loading)
- N/A (assumes prior protocol completed)
- Once weekly
- Ongoing (once per 7–10 days)
- Moderate. Fades without periodic dosing increase
- Appropriate for off-season maintenance when high-level protection isn't needed
- The clinical protocol produces the most consistent photoprotection with the fewest adverse events. Accelerated timelines work but increase gastrointestinal side effects and spontaneous erection frequency during the loading phase. Conservative protocols are appropriate when medical history (personal or family melanoma, dysplastic nevi) suggests caution. Slower pigmentation reduces the risk of exacerbating latent melanocytic instability.