Source comparison
Melanotan 1 vs 2: The Complete Comparison Table
Structure Linear peptide (13 amino acids) Cyclic peptide (7 amino acids) Receptor targets MC1R only (selective) MC1R + MC3R + MC4R + MC5R (non-selective) Primary effect Tanning (eumelanin synthesis) Tanning + libido + appetite suppression Tanning potency Stron
This comparison does not assign a generated winner or score.
- Structure
- Linear peptide (13 amino acids)
- Cyclic peptide (7 amino acids)
- Receptor targets
- MC1R only (selective)
- MC1R + MC3R + MC4R + MC5R (non-selective)
- Primary effect
- Tanning (eumelanin synthesis)
- Tanning + libido + appetite suppression
- Tanning potency
- Strong (dedicated MC1R activation)
- Strong (but shared across receptors)
- Libido effects
- Negligible (no MC4R activity)
- Significant (MC4R central arousal)
- Appetite effects
- None
- Mild suppression (MC4R/MC3R)
- Nausea risk
- Low
- Moderate (especially loading)
- Mole darkening
- Possible (mild)
- More pronounced
- Facial flushing
- Mild
- More common
- Regulatory status
- EU-approved (Scenesse)
- Not approved anywhere
- Half-life
- ~30 minutes
- ~1-2 hours
- Safety profile
- Better characterized (regulatory data)
- Less characterized
- Nasal spray
- Melanotan I Nasal Spray
- Melanotan II Nasal Spray
- Injectable
- $39.99