Source comparison
Melanotan-1 vs Melanotan-2: What Reddit Users Actually Prefer
MC1R Selectivity High selectivity. Minimal off-target binding Moderate selectivity. Binds MC1R, MC3R, MC4R, MC5R MT-1 preferred for tanning-only goals (78% of respondents) Tanning Onset 4–7 days visible pigmentation at 1mg daily 3–5 days visible pigmentation a
This comparison does not assign a generated winner or score.
- MC1R Selectivity
- High selectivity. Minimal off-target binding
- Moderate selectivity. Binds MC1R, MC3R, MC4R, MC5R
- MT-1 preferred for tanning-only goals (78% of respondents)
- Tanning Onset
- 4–7 days visible pigmentation at 1mg daily
- 3–5 days visible pigmentation at 0.5mg daily
- MT-2 faster but side effect trade-off not worth it for most
- Nausea Incidence
- 30–40% during loading phase
- 60–70% during loading phase
- MT-1 significantly better tolerated
- Sexual Side Effects
- Rare (spontaneous erections in <5% of male users)
- Common (spontaneous erections in 40–60% of male users)
- MT-1 strongly preferred by users avoiding sexual side effects
- Mole Darkening
- Minimal to none reported
- Pronounced darkening of existing moles in 50–70% of users
- MT-1 safer for users with numerous moles
- Maintenance Dose Frequency
- 0.5–1mg twice weekly
- 0.25–0.5mg twice weekly
- MT-2 requires less peptide but higher side effect burden
- Bottom Line
- Reddit consensus: MT-1 is the superior choice for cosmetic tanning without systemic complications. Slower onset is an acceptable trade-off for significantly reduced nausea, no unwanted erections, and minimal mole changes. MT-2's faster results come at the cost of tolerability for the majority of users.