Source comparison
Melanotan-2 and Erectile Dysfunction Research: Comparison
Wessells et al. (JAMA 2000) 20 men, psychogenic ED 0.025–0.1mg/kg SC 80% at 0.1mg/kg Placebo (10%) MC4R activation sufficient for penetration-grade erection in 80% of psychogenic ED cases MT-2 works when the problem is arousal signaling, not vascular damage Mo
This comparison does not assign a generated winner or score.
- Wessells et al. (JAMA 2000)
- 20 men, psychogenic ED
- 0.025–0.1mg/kg SC
- 80% at 0.1mg/kg
- Placebo (10%)
- MC4R activation sufficient for penetration-grade erection in 80% of psychogenic ED cases
- MT-2 works when the problem is arousal signaling, not vascular damage
- Molinoff et al. (Eur Urol 2003)
- 54 men, sildenafil non-responders
- 0.075mg/kg SC
- 64%
- No active comparator
- MT-2 produced response in nearly two-thirds of men who failed PDE5 inhibitor therapy
- Central mechanism complements, not replaces, vascular treatments
- Wessells et al. (Neuroscience 1998)
- Animal model
- 0.05mg/kg SC
- Erection despite hypogastric nerve section
- Sham surgery
- Effect persists without peripheral nerve input. Confirms central origin
- The mechanism is hypothalamic, not penile. This changes patient selection criteria