Source comparison
Melanotan-2 Clearance: Full Comparison Table
Blood Plasma 33 minutes (t½) Renal filtration and enzymatic degradation Undetectable after 2–3 hours Standard pharmacokinetic half-life. Does NOT predict biological effect duration Urine (intact peptide) Detectable 12–18 hours Glomerular filtration of unmetabo
This comparison does not assign a generated winner or score.
- Blood Plasma
- 33 minutes (t½)
- Renal filtration and enzymatic degradation
- Undetectable after 2–3 hours
- Standard pharmacokinetic half-life. Does NOT predict biological effect duration
- Urine (intact peptide)
- Detectable 12–18 hours
- Glomerular filtration of unmetabolised MT2
- Up to 24 hours post-injection
- Mass spectrometry required for detection; standard urinalysis will not identify MT2
- Tissue (melanocytes)
- 48–72 hours (receptor occupancy)
- MC1R binding and tyrosinase upregulation
- Pigmentation visible 24–96 hours
- Tanning effect peaks at 72 hours, persists 5–7 days as melanin granules shed
- Adipose Tissue
- 24–48 hours (depot release)
- Lipophilic partitioning and slow diffusion
- Not directly measurable
- Acts as secondary reservoir; higher body fat = slightly prolonged tanning duration
- Hypothalamus (MC4R sites)
- 2–4 days (functional suppression)
- MC4R-mediated appetite signalling reduction
- Appetite changes resolve 3–5 days post-dose
- Receptor downregulation occurs with chronic daily dosing; washout requires 7–10 days
- Complete System Clearance
- 5–7 days (all biological effects)
- Combination of renal excretion, receptor dissociation, melanin turnover
- No measurable tanning or appetite effect after 7 days
- Standard washout period for research protocols transitioning between peptides