Source comparison
Melanotan-2 PT-141 Stack Protocol: Peptide Type Comparison
Melanotan-2 MC1R, MC3R, MC4R, MC5R (non-selective) ~33 hours High. Strong MC1R agonism produces significant tanning Every 48–72 hours Broad melanocortin activation; suitable for sustained receptor occupancy and melanogenesis research PT-141 (Bremelanotide) MC3
This comparison does not assign a generated winner or score.
- Melanotan-2
- MC1R, MC3R, MC4R, MC5R (non-selective)
- ~33 hours
- High. Strong MC1R agonism produces significant tanning
- Every 48–72 hours
- Broad melanocortin activation; suitable for sustained receptor occupancy and melanogenesis research
- PT-141 (Bremelanotide)
- MC3R, MC4R (selective, minimal MC1R)
- 2–3 hours
- Minimal. Negligible MC1R binding
- 4–12 hours (or twice daily)
- Selective MC4R agonist; ideal for acute CNS and metabolic studies without melanogenesis confound
- Combined Stack
- Overlapping MC3R and MC4R, independent MC1R
- MT-2 sustained, PT-141 pulsatile
- Driven entirely by MT-2 component
- Staggered. MT-2 every 2–3 days, PT-141 as needed or twice daily
- Synergistic MC4R activation with MT-2 providing baseline and PT-141 adding acute peaks; requires precise timing