Source comparison
Melanotan-2 Sexual Health Research Evidence: Full Comparison
Men with psychogenic ED MC4R activation in hypothalamus + dopamine modulation 80% vs 10% placebo 37 min onset / 8 hr duration Nausea (30%), flushing (25%), no serious AEs Strongest evidence for CNS-mediated ED; outperformed placebo consistently across trials M
This comparison does not assign a generated winner or score.
- Men with psychogenic ED
- MC4R activation in hypothalamus + dopamine modulation
- 80% vs 10% placebo
- 37 min onset / 8 hr duration
- Nausea (30%), flushing (25%), no serious AEs
- Strongest evidence for CNS-mediated ED; outperformed placebo consistently across trials
- Men with organic ED (vascular/diabetic)
- MC4R + peripheral smooth muscle relaxation
- 60% vs 15% placebo
- 45 min onset / 6–8 hr duration
- Nausea (35%), GI discomfort (20%)
- Moderate efficacy; less effective than psychogenic cases but still clinically meaningful
- Women with HSDD
- Hypothalamic MC4R + dopamine reward pathways
- Significant desire increase vs placebo
- 60–90 min onset / 8–10 hr duration
- Nausea (40%), flushing (30%)
- Promising preliminary data; mechanism distinct from hormonal treatments
- Combination with PDE5 inhibitors
- Dual pathway (CNS arousal + NO-mediated vasodilation)
- No controlled trials
- Theoretical synergy untested
- Unknown interaction profile
- No published evidence; theoretically complementary but unstudied