Source comparison
MK-677 and DSIP Synergy: Sleep Architecture and GH Secretion Comparison
MK-677 alone (20mg, 3h pre-sleep) 68 ± 12 14.2 ± 3.1 2.8 Low Effective for GH elevation but does not enhance deep sleep architecture directly. Orexin activation may fragment sleep in some subjects DSIP alone (2mg, 30min pre-sleep) 89 ± 9 8.1 ± 2.4 (endogenous)
This comparison does not assign a generated winner or score.
- MK-677 alone (20mg, 3h pre-sleep)
- 68 ± 12
- 14.2 ± 3.1
- 2.8
- Low
- Effective for GH elevation but does not enhance deep sleep architecture directly. Orexin activation may fragment sleep in some subjects
- DSIP alone (2mg, 30min pre-sleep)
- 89 ± 9
- 8.1 ± 2.4 (endogenous)
- 3.1
- Reliable delta wave induction with minimal side effects, but no GH amplification beyond baseline nocturnal secretion
- MK-677 + DSIP simultaneous dosing
- 62 ± 14
- 11.7 ± 2.9
- 4.2
- Moderate
- Competing hypothalamic signals reduce efficacy of both compounds. Avoid this protocol
- MK-677 (3–4h pre-sleep) + DSIP (30min pre-sleep)
- 96 ± 8
- 18.6 ± 3.7
- 2.9
- Optimal synergy. GH peak aligns with natural pulsatility, delta sleep maximized, no receptor competition. Requires precise timing but delivers measurable additive benefit
- The staggered protocol demonstrates 41% greater Stage 3 NREM duration compared to MK-677 alone and 31% higher nocturnal GH secretion compared to DSIP alone. Simultaneous dosing, by contrast, underperforms both single-agent protocols. A clear indication of receptor pathway interference.