Source comparison
MK-677 Appetite Protocol: Method Comparison
Pre-meal acute dosing 60–90 minutes before target meal 12.5–25mg 90–150 minutes post-dose Single-meal appetite targeting, post-surgical recovery, chemotherapy-induced anorexia Most consistent method for subjects with predictable meal schedules. Relies on preci
This comparison does not assign a generated winner or score.
- Pre-meal acute dosing
- 60–90 minutes before target meal
- 12.5–25mg
- 90–150 minutes post-dose
- Single-meal appetite targeting, post-surgical recovery, chemotherapy-induced anorexia
- Most consistent method for subjects with predictable meal schedules. Relies on precise timing
- Morning daily dosing
- Upon waking, 90 minutes before breakfast
- 10–20mg
- Covers breakfast and early lunch
- Age-related appetite decline, general underfeeding, subjects who skip breakfast
- Works well for subjects with rigid AM routines, less effective if lunch timing varies
- Evening pre-dinner dosing
- 60–90 minutes before largest meal
- 15–25mg
- Covers dinner window, extends into evening snack
- Cachexia protocols, athletes in caloric surplus phases, night-shift workers
- High compliance because dinner is culturally the largest meal. Avoids daytime hunger conflicts
- Split-dose protocol
- 10mg AM + 10mg PM
- 20mg total daily (split)
- Two smaller peaks 90 min post-dose
- Severe appetite suppression requiring multi-meal support, paediatric protocols
- Smooths hunger across the day but requires strict adherence to two daily doses