Source comparison
MK-677 DSIP Sleep + GH Research: Dosing Comparison
Before initiating any protocol, researchers must understand the dosing ranges validated in controlled trials and the timing strategies that maximize bioavailability. MK-677 (ibutamoren) 10–25mg once daily 60–90 minutes before bed 4–6 hours (GH elevation persis
This comparison does not assign a generated winner or score.
- Before initiating any protocol, researchers must understand the dosing ranges validated in controlled trials and the timing strategies that maximize bioavailability.
- MK-677 (ibutamoren)
- 10–25mg once daily
- 60–90 minutes before bed
- 4–6 hours (GH elevation persists 24h)
- Mean 24h GH AUC, IGF-1 levels
- Dose-dependent GH increase plateaus above 25mg; night-time dosing aligns with natural GH pulse
- DSIP (delta sleep-inducing peptide)
- 50–150mcg subcutaneous
- 30 minutes before bed
- 15–20 minutes (effects last 6–8h)
- Slow-wave sleep % on PSG, subjective recovery
- Short plasma half-life but sustained sleep architecture effects; requires fresh reconstitution
- Combined MK-677 + DSIP
- 15mg MK-677 + 100mcg DSIP
- Both compounds 60 min pre-sleep
- See individual entries
- SWS duration, GH pulse amplitude, IGF-1
- Synergistic slow-wave extension (70–85 min increase vs 50 min MK-677 alone); 22–28% higher IGF-1 vs monotherapy