Source comparison
MK-677 DSIP Stack: Protocol Comparison
Standard Stack 25mg 90 min pre-sleep 150mcg 30 min pre-sleep Small protein meal with MK-677 20–30% improvement in subjective sleep quality, measurable delta-wave increase Optimal for most users. Timing aligns both mechanisms without interference Aggressive Sta
This comparison does not assign a generated winner or score.
- Standard Stack
- 25mg 90 min pre-sleep
- 150mcg 30 min pre-sleep
- Small protein meal with MK-677
- 20–30% improvement in subjective sleep quality, measurable delta-wave increase
- Optimal for most users. Timing aligns both mechanisms without interference
- Aggressive Stack
- 25mg 90 min pre-sleep + 25mg upon waking
- 200mcg 30 min pre-sleep
- Split dosing eliminates evening appetite spike
- 15–25% improvement. Twice-daily MK-677 reduces nocturnal GH peak slightly
- Effective for appetite-sensitive individuals, slight trade-off in peak GH amplitude
- MK-677 Monotherapy
- None
- 10–15% improvement. IGF-1 elevation without architecture protection
- Suboptimal. Addresses hormonal axis but not sleep fragmentation from cortisol
- DSIP Monotherapy
- Not applicable
- 12–18% improvement. Increased delta-wave density without sustained IGF-1
- Suboptimal. Improves sleep quality but no anabolic hormonal support
- Poorly Timed Stack
- 25mg at bedtime
- 150mcg 2 hours pre-sleep
- 0–5% improvement or worsening. Appetite disrupts onset, DSIP peaks too early
- Common error. Timing misalignment negates both compounds' benefits