Source comparison
MK-677 + DSIP Stack: Research Comparison
Mean 24h GH AUC Increase 60–97% vs baseline No direct GH effect 120–180% vs baseline Stack produces supra-additive GH output due to SWS extension during peak MK-677 activity Slow-Wave Sleep Duration Minimal change (~5–10 min increase) +30–50% vs baseline +35–5
This comparison does not assign a generated winner or score.
- Mean 24h GH AUC Increase
- 60–97% vs baseline
- No direct GH effect
- 120–180% vs baseline
- Stack produces supra-additive GH output due to SWS extension during peak MK-677 activity
- Slow-Wave Sleep Duration
- Minimal change (~5–10 min increase)
- +30–50% vs baseline
- +35–55% vs baseline
- DSIP drives the sleep benefit; MK-677 contributes modestly via reduced cortisol-mediated sleep fragmentation
- IGF-1 Elevation
- +40–60% at 25mg/day
- Negligible
- +55–75%
- Sustained GH pulsatility translates to IGF-1 synthesis; DSIP indirectly supports via cortisol modulation
- Sleep Latency Reduction
- No significant effect
- -12 to -18 minutes
- -15 to -20 minutes
- DSIP's primary mechanism; MK-677 does not independently reduce time to sleep onset
- Appetite Modulation
- Significant increase (orexigenic)
- Significant increase
- No synergy here. Appetite effect is purely MK-677-driven; DSIP does not counteract ghrelin signaling
- Cortisol Impact
- Transient early elevation (+15–25% weeks 1–2)
- -10 to -20% reduction in chronic stress models
- Net neutral to slight reduction
- DSIP offsets MK-677's early cortisol bump; combined effect favors GH signaling environment