Source comparison
MK-677 for Women 55+ Postmenopause: Comparison
MK-677 (25mg daily) Ghrelin receptor agonist; stimulates endogenous GH/IGF-1 release +2.1–3.8% lumbar spine, +1.5–2.1% femoral neck (RCT data) +1.0–1.5kg lean mass in IGF-1-depleted subjects; minimal effect if baseline IGF-1 >180 ng/mL +30–40 min slow-wave sle
This comparison does not assign a generated winner or score.
- MK-677 (25mg daily)
- Ghrelin receptor agonist; stimulates endogenous GH/IGF-1 release
- +2.1–3.8% lumbar spine, +1.5–2.1% femoral neck (RCT data)
- +1.0–1.5kg lean mass in IGF-1-depleted subjects; minimal effect if baseline IGF-1 >180 ng/mL
- +30–40 min slow-wave sleep; subjective improvement in 60–70% of users
- Effective for women with low baseline IGF-1; requires monitoring for insulin resistance and fluid retention
- Exogenous GH replacement (0.2–0.4mg daily)
- Direct GH supplementation; suppresses endogenous production
- +3.5–5.2% lumbar spine (higher magnitude than MK-677)
- +2.0–3.5kg lean mass; consistent across baseline IGF-1 levels
- Minimal impact on sleep architecture
- More potent anabolic effect but suppresses natural GH pulse; higher cost; requires prescription
- Bisphosphonates (alendronate 70mg weekly)
- Inhibits osteoclast activity; reduces bone resorption
- +4.0–6.5% lumbar spine (superior to secretagogues for bone alone)
- No lean mass benefit
- No impact
- Gold standard for osteoporosis but doesn't address sarcopenia or metabolic aging
- Resistance training (3x/week progressive overload)
- Mechanical loading; local IGF-1 expression in muscle
- +1.0–2.5% site-specific density (load-bearing sites only)
- +1.5–3.0kg lean mass (diet-dependent)
- Improves sleep latency; no direct SWS impact
- Non-pharmacological; requires consistency; synergistic with MK-677
- Estrogen HRT (transdermal 0.05mg)
- Restores estrogen receptor signalling; reduces bone resorption
- +2.0–4.0% lumbar spine; effect plateaus after 24 months
- Minimal lean mass impact
- Improves sleep continuity in women with vasomotor symptoms
- Addresses root hormonal cause but doesn't directly stimulate GH/IGF-1 axis