Source comparison
MK-677 Ipamorelin Stack Sleep and GH Protocol 2026: Sleep Stage Comparison
Stage 3 NREM Duration 45–60 min/night 68–82 min/night 48–63 min/night 74–91 min/night MK-677 directly extends deep sleep; stack provides 23–52% increase over baseline REM Latency 90–110 min 75–95 min 88–108 min 70–88 min Faster REM onset with stack improves sl
This comparison does not assign a generated winner or score.
- Stage 3 NREM Duration
- 45–60 min/night
- 68–82 min/night
- 48–63 min/night
- 74–91 min/night
- MK-677 directly extends deep sleep; stack provides 23–52% increase over baseline
- REM Latency
- 90–110 min
- 75–95 min
- 88–108 min
- 70–88 min
- Faster REM onset with stack improves sleep efficiency and next-day cognitive function
- Night Wakings
- 3–5 episodes
- 2–4 episodes
- 1–3 episodes
- Stack reduces fragmentation. Likely from sustained GH maintaining glucose stability
- Total Sleep Time
- 6.5–7.2 hours
- 7.0–7.8 hours
- 6.6–7.3 hours
- 7.2–8.1 hours
- MK-677's sedative effect at higher doses extends sleep duration; stack optimizes without oversedation
- Subjective Sleep Quality (1–10 scale)
- 5.5–6.8
- 7.2–8.1
- 6.0–7.0
- 7.8–8.9
- Stack consistently rated highest for restorative quality and next-day energy
- The comparison shows that while MK-677 alone produces significant sleep architecture improvements, the stack with properly timed ipamorelin enhances nearly every measurable parameter. The key differentiator is receptor pathway separation. MK-677 works through ghrelin pathways to sustain overnight GH elevation, while morning ipamorelin generates a discrete pulse through GHRP receptors that supports daytime recovery without blunting nighttime effects.