Source comparison
MK-677 Muscle Recovery Protocol Dosage Timing Comparison
Precede every comparison with context. The table below shows how different MK-677 dosing schedules affect recovery markers, based on published clinical trials and metabolic studies measuring GH pulse amplitude, IGF-1 levels, and muscle protein synthesis rates.
This comparison does not assign a generated winner or score.
- Precede every comparison with context. The table below shows how different MK-677 dosing schedules affect recovery markers, based on published clinical trials and metabolic studies measuring GH pulse amplitude, IGF-1 levels, and muscle protein synthesis rates.
- Evening (Pre-Sleep)
- 25mg
- 97% increase vs baseline
- 60–90%
- Optimal. Synchronizes with nocturnal repair window, maximizes overnight MPS
- Gold standard for muscle recovery; aligns pharmacokinetics with circadian GH release
- Morning (Fasted)
- 31% increase vs baseline
- 40–55%
- Suboptimal. Misses sleep-dependent anabolic surge, lower total GH exposure
- Functional for IGF-1 elevation but misses peak recovery period
- Split Dosing (AM/PM)
- 12.5mg × 2
- 45% increase vs baseline
- 50–70%
- Moderate. Maintains stable IGF-1 but dilutes nocturnal pulse
- Not superior to single evening dose; increases complexity without benefit
- Post-Workout
- 28% increase vs baseline
- 35–50%
- Poor. GH pulse occurs hours after dosing; misses overnight repair
- Timing disconnects from natural circadian peak; wastes the compound's pulsatile mechanism