Source comparison
MK-677 Nitrogen Retention: Study Comparison
Healthy elderly (65+ years) 25 12 +2.1 kg lean body mass vs placebo Statistically significant nitrogen retention begins at week 8; peaks at week 12 GH-deficient adults 24 +3.8 kg lean mass, improved nitrogen balance by week 16 Larger effect in GH-deficient pop
This comparison does not assign a generated winner or score.
- Healthy elderly (65+ years)
- 25
- 12
- +2.1 kg lean body mass vs placebo
- Statistically significant nitrogen retention begins at week 8; peaks at week 12
- GH-deficient adults
- 24
- +3.8 kg lean mass, improved nitrogen balance by week 16
- Larger effect in GH-deficient populations; nitrogen retention sustained through 24 weeks
- Obese subjects (caloric deficit)
- 8
- Preserved lean mass during weight loss; no net nitrogen gain
- MK-677 prevents muscle loss during deficit but does not override caloric restriction
- Healthy young adults (20–30 years)
- 10–25
- Minimal lean mass change; IGF-1 elevated but no significant nitrogen retention
- Limited anabolic effect in subjects with intact GH secretion
- Resistance-trained adults + MK-677
- +4.2 kg lean mass vs +1.8 kg training-only group
- Synergistic effect with resistance training; nitrogen retention amplified by mechanical loading