Source comparison
MK-677 Oral GH Secretagogue Protocol: Research Application Comparison
Starting Dose 25mg daily from day one 10mg daily, escalate weekly 5–10mg daily, hold 2 weeks before escalation Circadian-optimised reduces early dropout due to side effects while maintaining endpoint IGF-1 elevation. Standard dosing front-loads discomfort Admi
This comparison does not assign a generated winner or score.
- Starting Dose
- 25mg daily from day one
- 10mg daily, escalate weekly
- 5–10mg daily, hold 2 weeks before escalation
- Circadian-optimised reduces early dropout due to side effects while maintaining endpoint IGF-1 elevation. Standard dosing front-loads discomfort
- Administration Timing
- Morning with breakfast
- 90–120 min before sleep, fasted
- Evening, 3+ hours post-meal
- Evening fasted dosing increases GH pulse amplitude 40–60% vs fed or morning administration. Timing matters more than dose magnitude
- Glucose Monitoring Frequency
- Pre-study baseline only
- Weekly fasting glucose first month
- Twice-weekly for 6 weeks
- Insulin resistance unmasking occurs in 15–20% of users by week 3. Weekly checks catch it before it disrupts the protocol
- IGF-1 Assessment Schedule
- Baseline and week 12
- Baseline, week 4, week 8, week 12
- Baseline, week 2, week 4, then monthly
- Week 4 IGF-1 predicts responder status. Waiting until week 12 wastes 8 weeks if the protocol isn't working
- Dose Adjustment Trigger
- None. Fixed dose
- Reduce if fasting glucose >100 mg/dL
- Reduce if appetite disrupts sleep or glucose >95 mg/dL
- Metabolic disruption (elevated glucose, severe hunger) signals the dose exceeds the body's compensatory capacity. Lowering dose preserves long-term adherence