Source comparison
MK-677 Recovery Results Timeline: Comparison by Domain
Sleep Quality 7–14 days Enhanced Stage 4 and REM sleep via GH pulse amplification during deep sleep Subjective: deeper sleep, reduced waking, improved morning energy Earliest and most consistent marker. If sleep doesn't improve by Week 2, dosing or timing may
This comparison does not assign a generated winner or score.
- Sleep Quality
- 7–14 days
- Enhanced Stage 4 and REM sleep via GH pulse amplification during deep sleep
- Subjective: deeper sleep, reduced waking, improved morning energy
- Earliest and most consistent marker. If sleep doesn't improve by Week 2, dosing or timing may be suboptimal
- IGF-1 Elevation
- 10–14 days
- Hepatic IGF-1 synthesis in response to sustained GH signaling
- Blood work: 40–60% increase in serum IGF-1 above baseline
- Confirms mechanism is active. Absence of IGF-1 rise suggests product integrity or absorption issue
- Soft Tissue Repair
- 6–8 weeks
- Fibroblast proliferation, collagen synthesis in tendons/ligaments
- Reduced joint pain on loading, faster recovery from high-volume training
- Functional marker. Earlier than structural imaging can detect tissue changes
- Lean Mass Gain
- 12–16 weeks
- Cumulative protein accretion from sustained positive nitrogen balance
- DEXA scan: 1–2kg lean mass increase at 12 weeks, 2–3kg at 24 weeks
- Requires concurrent resistance training and adequate protein intake (1.6–2.2g/kg)
- Bone Density
- 16–24 weeks
- Shift in osteoblast/osteoclast balance toward net bone formation
- DEXA scan: 2–4% increase in BMD at load-bearing sites
- Slowest-responding domain. Protocols shorter than 16 weeks are insufficient for bone outcomes
- Fat Mass Reduction
- 12–20 weeks
- GH-mediated lipolysis, improved insulin sensitivity, nutrient partitioning
- DEXA scan: 0.5–1.5kg fat loss at 12 weeks, continued reduction through 24 weeks
- Secondary effect. Not the primary mechanism; requires caloric control