Source comparison
MK-677 Results After 1 Week: Comparison to Other Compounds
MK-677 GHSR-1a agonist (ghrelin mimetic) Improved sleep, increased appetite, mild bloating IGF-1 +30–50% by day 7, water retention +1–2 kg 4–8 weeks for lean mass, 6–10 weeks for fat loss Non-suppressive; effects cumulative over months Recombinant GH Exogenous
This comparison does not assign a generated winner or score.
- MK-677
- GHSR-1a agonist (ghrelin mimetic)
- Improved sleep, increased appetite, mild bloating
- IGF-1 +30–50% by day 7, water retention +1–2 kg
- 4–8 weeks for lean mass, 6–10 weeks for fat loss
- Non-suppressive; effects cumulative over months
- Recombinant GH
- Exogenous growth hormone
- Improved sleep, joint discomfort (rare), mild bloating
- IGF-1 +100–200% by day 3, water retention +2–4 kg
- 3–6 weeks for lean mass, 4–8 weeks for fat loss
- Suppresses endogenous GH; requires daily injection
- GHRP-6
- Growth hormone secretagogue (peptide)
- Intense hunger within 20 min, no sleep effect
- GH pulse +200–400% acutely, no sustained IGF-1 rise
- No body composition effect from pulsatile-only dosing
- Must dose 3–4× daily; acute GH spike without IGF-1 elevation
- CJC-1295 + Ipamorelin
- GHRH analog + GHRP
- Minimal week-one effects
- Modest IGF-1 rise (+20–40%) by day 10
- 5–9 weeks for lean mass
- Requires frequent dosing; less consistent than MK-677
- Testosterone (TRT dose)
- Androgen receptor agonist
- Improved mood, libido increase, no sleep change
- No measurable body composition change
- 6–10 weeks for lean mass, 8–12 weeks for fat loss
- Suppresses natural testosterone; requires PCT if cycled
- MK-677 produces the most consistent early sleep and appetite changes of any growth hormone modulator, but the slowest body composition timeline. Individuals expecting visual results comparable to exogenous testosterone or recombinant GH within one week will be disappointed. The compound's strength is sustained, non-suppressive IGF-1 elevation over months, not rapid transformation.