Source comparison
MK-677 Results After 2 Weeks vs 8–12 Weeks: Comparison
Serum IGF-1 Elevation 55–90% above baseline (confirmed via blood test) Sustained at 60–100% above baseline (plateau by week 6) IGF-1 peaks early; tissue adaptation lags behind plasma concentration by 6–8 weeks Lean Body Mass (LBM) No measurable change (±0.5 lb
This comparison does not assign a generated winner or score.
- Serum IGF-1 Elevation
- 55–90% above baseline (confirmed via blood test)
- Sustained at 60–100% above baseline (plateau by week 6)
- IGF-1 peaks early; tissue adaptation lags behind plasma concentration by 6–8 weeks
- Lean Body Mass (LBM)
- No measurable change (±0.5 lbs is noise)
- 2–4 lbs net gain if caloric surplus and resistance training present
- Muscle protein synthesis increases modestly by week 2 but net accretion requires 8+ weeks of sustained anabolic signaling
- Fat Mass
- No measurable change
- 1–3 lbs reduction if caloric deficit maintained
- Lipolysis rate increases slightly under elevated GH/IGF-1 but fat loss is diet-driven, not compound-driven
- Sleep Quality
- Noticeable improvement (deeper REM, fewer wake episodes)
- Sustained improvement (10–20% increase in REM duration via polysomnography)
- Sleep benefits are among the earliest and most consistent effects. Present by day 5–7
- Appetite
- Moderate increase (15–30% higher intake if unrestricted)
- Sustained elevation; appetite remains 20–40% above baseline
- Ghrelin mimetic effect is immediate and dose-dependent. Appetite increase confirms receptor binding
- Water Retention
- 2–4 lbs extracellular fluid (hands, ankles, face)
- Partially resolves by week 6–8 as kidneys adapt to elevated IGF-1
- Early fluid retention is temporary; chronic edema signals poor renal adaptation or excessive dose