Source comparison
MK-677 Results Timeline: Phase Comparison
Neurological Response 24–72 hours Ghrelin receptor activation in hypothalamus Increased appetite, improved sleep architecture (REM and slow-wave stages) 50% increase in REM sleep duration within 7 days Earliest and most consistent marker. If sleep quality does
This comparison does not assign a generated winner or score.
- Neurological Response
- 24–72 hours
- Ghrelin receptor activation in hypothalamus
- Increased appetite, improved sleep architecture (REM and slow-wave stages)
- 50% increase in REM sleep duration within 7 days
- Earliest and most consistent marker. If sleep quality doesn't improve within one week, dosing or purity may be insufficient
- Recovery & Tissue Remodeling
- 2–4 weeks
- IGF-1-mediated collagen synthesis, mTOR pathway activation
- Faster DOMS recovery, skin elasticity improvement, hair growth acceleration
- 18–25% faster recovery of force production post-exercise
- Subjective improvements are reliable at this phase. Objective measures (DEXA, imaging) are premature
- Body Composition Shift
- 8–16 weeks
- Sustained elevation of GH/IGF-1 driving protein synthesis and lipolysis
- Lean mass gain (1–2kg), visceral fat reduction (5–10%), improved muscle fullness
- Mean 1.1kg fat-free mass increase at 8 weeks with resistance training
- This is the outcome window most users target. Patience and consistency separate responders from non-responders
- Metabolic Adaptation
- 8–12 weeks
- GH counter-regulatory effect on insulin, hepatic glucose output
- Fasting glucose increase (5–15 mg/dL), possible transient insulin resistance
- Fasting glucose elevation detectable by week 4–6
- Monitor glucose closely if diabetic or pre-diabetic. Most healthy subjects tolerate this without progression
- Bone & Connective Tissue
- 12–24 months
- Osteoblast stimulation, chondrocyte proliferation, tendon remodeling
- Increased BMD (2–5%), cartilage thickness improvement, joint structural integrity
- Significant BMD changes not detectable until month 9+
- Longest timeline of any outcome. This is not a short-term intervention