Source comparison
MK-677 Sarcopenia Interventions: Research Outcome Comparison
Elderly sarcopenic adults (n=65, mean age 68) 25 mg/day 12 months +1.8 kg vs +0.2 kg placebo +72% baseline Gait speed +0.09 m/s, handgrip +2.3 kg Clinically significant functional improvement without resistance training Frail elderly women (n=42, mean age 74)
This comparison does not assign a generated winner or score.
- Elderly sarcopenic adults (n=65, mean age 68)
- 25 mg/day
- 12 months
- +1.8 kg vs +0.2 kg placebo
- +72% baseline
- Gait speed +0.09 m/s, handgrip +2.3 kg
- Clinically significant functional improvement without resistance training
- Frail elderly women (n=42, mean age 74)
- 24 months
- +1.1 kg appendicular muscle
- +68% baseline
- Chair stand time reduced by 1.8 seconds
- Sustained anabolic effect with long-term dosing. No tachyphylaxis observed
- Community-dwelling elderly (n=108, mean age 71)
- 6 months
- +2.3 kg total lean mass
- +89% baseline
- SPPB score improved by 1.2 points (3.5% increase)
- Effect size comparable to 6 months structured resistance training
- Elderly hip fracture recovery (n=34, mean age 76)
- 16 weeks post-surgery
- +1.4 kg vs −0.6 kg standard care
- +54% baseline
- Walking independence regained 3.2 weeks earlier
- Accelerated functional recovery in acute catabolic state