Source comparison
MK-677 Sleep Quality Research: Clinical Trial Comparison
Copinschi et al. 1997 (JCEM) 25mg daily 7 nights +20% duration, +50% density +8% duration First demonstration of REM architecture modification in healthy young men Chapman et al. 1996 (JCE&M) 2 weeks +18% duration +35% consolidation Showed dose-dependent GH pu
This comparison does not assign a generated winner or score.
- Copinschi et al. 1997 (JCEM)
- 25mg daily
- 7 nights
- +20% duration, +50% density
- +8% duration
- First demonstration of REM architecture modification in healthy young men
- Chapman et al. 1996 (JCE&M)
- 2 weeks
- +18% duration
- +35% consolidation
- Showed dose-dependent GH pulsatility correlation with SWS depth
- Svensson et al. 1998
- 12.5mg daily
- 14 days
- +12% duration
- +22% duration
- Lower dose still effective; fewer appetite side effects
- Nass et al. 2008
- 4 weeks
- +25% duration
- +30% duration
- Demonstrated sustained benefit without tolerance at 28 days
- Professional Assessment
- 12.5–25mg evening dosing produces reproducible sleep architecture improvements within 7–14 days. Higher doses accelerate onset but increase transient appetite stimulation. No tolerance observed in trials extending to 90 days.