Source comparison
MK-677 Storage: Lyophilised vs Reconstituted Comparison
Unreconstituted lyophilised powder −20°C (long-term) or 2–8°C (short-term) Up to 25°C for 24–48 hours Weeks at room temperature before irreversible oxidation Return to −20°C immediately; use within next research cycle Nearly always salvageable if powder remain
This comparison does not assign a generated winner or score.
- Unreconstituted lyophilised powder
- −20°C (long-term) or 2–8°C (short-term)
- Up to 25°C for 24–48 hours
- Weeks at room temperature before irreversible oxidation
- Return to −20°C immediately; use within next research cycle
- Nearly always salvageable if powder remains white and dry
- Reconstituted solution (mixed with bacteriostatic water)
- 2–8°C (strict requirement)
- No safe excursion—degradation begins above 8°C
- 4–6 hours at 20–25°C before 30%+ potency loss
- If <6 hours at room temp: refrigerate and use within 48 hours; if >12 hours: discard
- Salvage possible only if exposure was brief (<4 hours) and solution remains clear
- Partially used reconstituted vial
- 2–8°C (refrigerate between uses)
- None—each temperature excursion compounds degradation
- Cumulative exposure accelerates decline
- Minimise time out of fridge during dosing; never leave at room temp between doses
- Repeated excursions degrade faster than single long exposure