Source comparison
MK-677 Studied Sarcopenia Research: Full Comparison
University of Virginia 2008 (JCEM) 65 adults aged 60–81 with functional impairment 12 months 25mg daily +1.1kg vs placebo (p<0.01) No change in gait speed, grip strength, or stair climb power Lean mass gains without functional improvement. Anabolic effect conf
This comparison does not assign a generated winner or score.
- University of Virginia 2008 (JCEM)
- 65 adults aged 60–81 with functional impairment
- 12 months
- 25mg daily
- +1.1kg vs placebo (p<0.01)
- No change in gait speed, grip strength, or stair climb power
- Lean mass gains without functional improvement. Anabolic effect confirmed but insufficient for sarcopenia reversal
- Hip Fracture Recovery Study 2013 (GH&IGF Research)
- 123 hip fracture patients aged 65+
- +1.8kg vs placebo
- No difference in time to ambulation, hospital stay, or post-discharge falls
- Largest absolute lean mass gain observed, but no translation to rehabilitation outcomes
- Elderly Frailty Trial 2015 (Age and Ageing)
- 89 frail adults aged 70+
- 24 weeks
- +0.8kg vs placebo
- Modest improvement in handgrip strength (+1.2kg, p=0.04) but no change in gait or ADL scores
- Only trial showing any functional benefit. Effect size too small to meet clinical significance threshold