Source comparison
MK-677 vs. Ipamorelin | Comprehensive Comparison
Both MK-677 and ipamorelin significantly increase GH and IGF-1 levels in test subjects. For example, here is a timeline of GH-related effects following a single ipamorelin administration in healthy adults [11]: Subcutaneous application of ipamorelin significan
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- Both MK-677 and ipamorelin significantly increase GH and IGF-1 levels in test subjects.
- For example, here is a timeline of GH-related effects following a single ipamorelin administration in healthy adults [11]:
- Subcutaneous application of ipamorelin significantly elevates GH levels within 40 minutes.
- With a half-life under 2 hours, it was noted that ipamorelin’s GH-boosting effect persists for 2-3 hours following subcutaneous injection.
- Study authors reported that ipamorelin doses at both 60mcg/kg and 100mcg/kg of body weight can lead to similar GH increases: about 26.6ng/ml (80mIU/l) peak GH.
- In addition, studies in laboratory animals report a 54% increase in IGF-I following ipamorelin application [12].
- On the other hand, studies report that MK-677 has a considerably longer half-life of 4-6 hours, and daily oral intake can significantly increase GH and IGF-1 levels [5, 7].
- A trial in 32 healthy older adults reported the following findings [13]:
- When taken as 10mg or 25mg/daily capsules, MK-677 increased mean 24-h GH concentration by 57% and 97%, respectively.
- Pulsatile GH-release increased 1.7-fold over 24 hours.
- Daily administration led to a 55% increase in IGF-1 levels at 2 weeks and 88% at 4 weeks.
- In addition, MK-677 was reported to cause a dramatic 55.6ng/ml peak in GH levels after a single 25mg dose when combined with caloric restriction [14].
- Based on these findings, both ipamorelin and MK-677 appear to increase GH levels significantly, although the GH peak with MK-677 appears to be greater.