Source comparison
MK-677 vs Research Peptides: Mechanism Comparison
MK-677 Ghrelin receptor (GHSR-1a) Oral, once daily Sustained 24-hour elevation 4–6 hours (effect duration: 24h) Metabolic studies, chronic GH deficiency models, appetite regulation Moderate. Stimulates appetite, mild insulin resistance in 15–20% GHRP-2 GHS-R +
This comparison does not assign a generated winner or score.
- MK-677
- Ghrelin receptor (GHSR-1a)
- Oral, once daily
- Sustained 24-hour elevation
- 4–6 hours (effect duration: 24h)
- Metabolic studies, chronic GH deficiency models, appetite regulation
- Moderate. Stimulates appetite, mild insulin resistance in 15–20%
- GHRP-2
- GHS-R + ghrelin pathways
- Subcutaneous injection, 2–3x daily
- Pulsatile, peaks at 30–90 min
- 20–30 minutes
- Acute GH pulse studies, synergistic protocols with GHRH analogs
- Low. Stimulates cortisol and prolactin alongside GH
- GHRP-6
- Appetite stimulation research, GH pulse characterization
- Low. Strongest appetite effect, elevates cortisol
- Ipamorelin
- GHS-R1a (selective)
- ~2 hours
- Lean mass studies, protocols requiring minimal side effects
- High. No appetite or cortisol stimulation
- CJC-1295 (DAC)
- GHRH receptor
- Subcutaneous injection, 1–2x weekly
- Sustained for 6–8 days
- 6–8 days
- Long-duration protocols, reduced injection frequency
- Moderate. Requires endogenous GHRH rhythm