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MK-677 vs. Sermorelin | Comprehensive Comparison
While the two may have some similar effects, MK-677 and sermorelin have vastly different structures and mechanisms. MK-677 is a non-peptide growth hormone secretagogue with affinity to the ghrelin receptors, while sermorelin is a peptide agonist of the GHRH re
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- While the two may have some similar effects, MK-677 and sermorelin have vastly different structures and mechanisms.
- MK-677 is a non-peptide growth hormone secretagogue with affinity to the ghrelin receptors, while sermorelin is a peptide agonist of the GHRH receptors of the pituitary gland.
- Both compounds are highly effective at increasing GH and related hormones, including IGF-1, which is growth hormone’s main anabolic mediator.
- Here is what researchers should know about the impact of sermorelin administration on GH and IGF-1 secretion.
- In a study in elderly individuals, sermorelin was reported to cause up to a 107% increase in mean 24-hour GH levels and a 28% increase in mean IGF-1 levels in treated men [12]. In another study in 11 elderly male participants, each receiving sermorelin 2mg/daily as a single subcutaneous injection, elevated GH concentrations remained for about two hours following each injection [13].
- Sermorelin has also been applied as twice-daily injections (morning and evening) at a dose of 1mg per shot. In a study in elderly men that applied this regimen, the researchers reported a 64% increase in the participants’ mean 24-hour GH levels, with a higher increase after the evening injection [14].
- Similarly, clinical testing of MK-677 has shown impressive increases in GH and IGF-1 levels, even after a single administration:
- A study in eight healthy volunteers, each given a single 25mg MK-677 dose combined with caloric restriction, reported that the GHS led to a dramatic 55.9ng/ml peak in GH levels [15]. As a reference, physiological GH peaks are within the range of 10-14ng/ml.
- A trial in 32 healthy older adults reported that MK-677 at 25mg/daily increased the mean 24h GH concentration by 97%, while pulsatile GH release increased by 1.7-fold. Moreover, daily administration led to a 55% increase in IGF-1 levels at two weeks and 88% at four weeks [16].
- Given these similarities and differences between MK-677 and sermorelin, let’s now delve deeper into the findings of key clinical studies involving both compounds.