Source comparison
MOTS-c 40s Age Specific Protocol: Comparison Table
Dose per injection 2.5–5mg 5–10mg 7.5–12.5mg Higher doses compensate for reduced mitochondrial density; age 40+ requires 50–100% dose increase vs younger populations to achieve equivalent AMPK activation Injection frequency 1–2x weekly 2–3x weekly 3–4x weekly
This comparison does not assign a generated winner or score.
- Dose per injection
- 2.5–5mg
- 5–10mg
- 7.5–12.5mg
- Higher doses compensate for reduced mitochondrial density; age 40+ requires 50–100% dose increase vs younger populations to achieve equivalent AMPK activation
- Injection frequency
- 1–2x weekly
- 2–3x weekly
- 3–4x weekly
- Frequency increases with age to maintain consistent plasma levels despite declining mitochondrial responsiveness; more frequent lower doses outperform less frequent higher doses
- Timing relative to exercise
- Flexible (pre or post)
- Pre-fasted cardio (30–60 min before)
- Pre-fasted cardio + pre-resistance training
- Metabolic window alignment becomes critical after 40; fasted-state administration amplifies AMPK response by 30–40% vs fed-state dosing
- Dietary context
- Standard meals acceptable
- 4–6 hour fast before injection
- 6–8 hour fast before injection
- Insulin suppresses AMPK; longer fasting windows required with age to overcome baseline insulin resistance and maximize peptide uptake
- Expected fat loss timeline
- 4–6 weeks for measurable change
- 6–8 weeks for measurable change
- 8–12 weeks for measurable change
- Mitochondrial adaptation timelines extend with age; patience required. MOTS-c isn't a rapid-onset compound at any age
- Reconstituted storage duration
- Up to 30 days at 2–8°C
- 21–28 days recommended
- 14–21 days recommended
- Peptide stability decreases slightly with repeated vial access; older adults using higher doses per injection consume vials faster, reducing degradation risk