Source comparison
MOTS-c Animal Research: Model Comparison
Diet-Induced Obesity (C57BL/6 mice, 60% HFD) 5 mg/kg/day IP 58% reduction in fasting insulin; glucose tolerance restored to baseline AMPK activation in skeletal muscle; GLUT4 translocation independent of insulin signaling 3 weeks Insulin resistance reversal oc
This comparison does not assign a generated winner or score.
- Diet-Induced Obesity (C57BL/6 mice, 60% HFD)
- 5 mg/kg/day IP
- 58% reduction in fasting insulin; glucose tolerance restored to baseline
- AMPK activation in skeletal muscle; GLUT4 translocation independent of insulin signaling
- 3 weeks
- Insulin resistance reversal occurs before significant weight loss. Metabolic shift precedes phenotype change
- Aging Intervention (18-month-old mice)
- 15 mg/kg every other day IP
- 22% increase in mitochondrial respiration (OCR); 19% improvement in grip strength
- Reduced mitochondrial proton leak; enhanced coupling efficiency
- 8 weeks
- Age-related mitochondrial dysfunction is partially reversible through peptide administration without caloric restriction
- Exercise Performance (young sedentary mice)
- 5 mg/kg/day IP + voluntary wheel access
- 34% increase in running time to exhaustion; Type I fiber proportion increased from 38% to 52% in soleus muscle
- PGC-1alpha upregulation; mitochondrial biogenesis in oxidative muscle fibers
- 6 weeks
- Peptide enhances training adaptation beyond exercise stimulus alone. Not a performance enhancer in untrained state