Source comparison
MOTS-c Anti-Aging Protocol Dosage Timing: Comparison of Administration Schedules
3× weekly (M/W/F) 15–30mg total Morning fasted, 30–60 min post-waking High. Matches natural AMPK rhythm Low. Simple pattern Optimal balance of efficacy and practicality; most research protocols use this schedule Every other day (3.5×/week) 17.5–35mg total Morn
This comparison does not assign a generated winner or score.
- 3× weekly (M/W/F)
- 15–30mg total
- Morning fasted, 30–60 min post-waking
- High. Matches natural AMPK rhythm
- Low. Simple pattern
- Optimal balance of efficacy and practicality; most research protocols use this schedule
- Every other day (3.5×/week)
- 17.5–35mg total
- Morning fasted, rotating days
- High. Maintains circadian consistency
- Moderate. Requires calendar tracking
- Slightly higher weekly exposure; useful for advanced protocols seeking maximal signaling
- 2× weekly (widely spaced)
- 10–20mg total
- Morning fasted, 72–96 hours apart
- Moderate. Longer gaps between signals
- Very low. Easy to remember
- Minimum viable frequency; suitable for maintenance phases after initial adaptation period
- Daily microdosing
- 14–35mg total
- Morning fasted, daily
- High. Daily circadian reset
- High. Requires daily commitment
- Not recommended. Doesn't allow metabolic recovery between doses; produces receptor fatigue
- Random timing (control)
- Variable
- No timing protocol
- None. Circadian desynchronization
- N/A
- Ineffective. Research shows 40–60% reduction in metabolic markers vs timed protocols