Source comparison
MOTS-C Cycle: Protocol Comparison
4 weeks 5–10mg Once weekly 14–21 days Standard metabolic cycle for glucose regulation and fat oxidation USC rodent studies, human case series Most reliable protocol for first-time users. Balances efficacy with minimal adaptation risk 6 weeks 10mg 21–28 days Ex
This comparison does not assign a generated winner or score.
- 4 weeks
- 5–10mg
- Once weekly
- 14–21 days
- Standard metabolic cycle for glucose regulation and fat oxidation
- USC rodent studies, human case series
- Most reliable protocol for first-time users. Balances efficacy with minimal adaptation risk
- 6 weeks
- 10mg
- 21–28 days
- Extended cycle for body recomposition during caloric deficit
- Limited direct evidence; extrapolated from AMPK pathway dynamics
- Acceptable if measurable benefit persists past week four, but requires longer washout to reset receptor sensitivity
- 3 weeks
- 15mg
- Twice weekly
- 14 days
- High-intensity short cycle for acute metabolic intervention
- Used in some athletic research contexts; safety data sparse above 10mg weekly
- Not recommended. Higher dose doesn't proportionally increase AMPK activation due to saturation, and abbreviated washout risks diminished second-cycle response
- 8+ weeks continuous
- Variable
- Ongoing
- None
- Chronic administration without cycling
- No published support; likely produces receptor downregulation by week six
- Avoid entirely. Defeats the mechanism that makes MOTS-C effective; adaptation eliminates metabolic benefit