Source comparison
MOTS-c Dosage Protocol Guide: Comparison
5mg Mitochondrial biogenesis studies without confounding caloric restriction effects Moderate (12–15% insulin sensitivity improvement) 8–12 weeks 2.5mL (2mg/mL concentration) 28 days at 2–8°C 10mg Metabolic research (glucose disposal, insulin sensitivity, fat
This comparison does not assign a generated winner or score.
- 5mg
- Mitochondrial biogenesis studies without confounding caloric restriction effects
- Moderate (12–15% insulin sensitivity improvement)
- 8–12 weeks
- 2.5mL (2mg/mL concentration)
- 28 days at 2–8°C
- 10mg
- Metabolic research (glucose disposal, insulin sensitivity, fat oxidation)
- High (25–30% insulin sensitivity improvement)
- 8–16 weeks
- 5mL (2mg/mL concentration)
- 15mg
- Maximal metabolic effect research, exercise performance studies
- Maximal (30–34% insulin sensitivity improvement)
- 12–16 weeks
- 7.5mL (2mg/mL concentration)
- >15mg
- Not standard. No additional benefit observed in published research
- No incremental benefit beyond 15mg saturation point
- N/A
- Most research contexts use 10mg as the standard weekly dose. Doses below 5mg are uncommon because they fail to produce statistically significant metabolic changes in most models. Doses above 15mg do not improve outcomes and introduce unnecessary cost without therapeutic justification.