Source comparison
MOTS-c Endurance Protocol: Dose Comparison
Total Weekly Exposure 10mg 15mg 30mg Standard dose (15mg/week) matches published human trials and balances efficacy with cost. Low dose shows benefit in preclinical models but human data is limited Plasma AMPK Activation Duration 18–24 hours post-injection 36–
This comparison does not assign a generated winner or score.
- Total Weekly Exposure
- 10mg
- 15mg
- 30mg
- Standard dose (15mg/week) matches published human trials and balances efficacy with cost. Low dose shows benefit in preclinical models but human data is limited
- Plasma AMPK Activation Duration
- 18–24 hours post-injection
- 36–48 hours cumulative
- 48–60 hours cumulative
- Frequent low doses outperform infrequent high doses because AMPK phosphorylation requires sustained exposure, not peak concentration
- Mitochondrial Biogenesis Timeframe
- 6–8 weeks
- 4–6 weeks
- 4–5 weeks
- Higher doses compress adaptation timeline slightly but do not double effect magnitude. Diminishing returns above 15mg/week
- Insulin Sensitivity Impact
- Mild improvement (~8% fasting glucose reduction)
- Moderate improvement (~12–15% reduction)
- Pronounced improvement (~18–20% reduction)
- Athletes on low-carb protocols should monitor glucose closely at high doses to prevent hypoglycemia during fasted training
- Cost Per 8-Week Cycle
- $240–320
- $360–480
- $720–960
- Standard dose offers best cost-efficacy ratio. High dose justified only for elite athletes in short preparation windows
- Injection Site Reactions
- Minimal
- Minimal to moderate
- Moderate (lipohypertrophy risk with poor site rotation)
- Rotate abdominal quadrants regardless of dose; higher frequency increases localized tissue stress if sites repeat within 7 days